Votre recherche pour: WLD-TEC+GmbH

Numéro de catalogue: (HEID591-00095-00)

Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Sound absorber for all Hei-VAC vacuum pumps

UOM: 1 * 1 ST

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Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Sonde température de vapeur: Pour les modèles Advantage et Precision uniquement
- Affichage de la température de vapeur.

Numéro de catalogue: (HEID518-41100-00)

Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Hei-VAP Industrial - All-round Package.

UOM: 1 * 1 ST

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Numéro de catalogue: (201-0126)

Fournisseur: Lenz Laborglas GmbH & CO.KG

Description: En PTFE blanc

UOM: 1 * 1 ST

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Fournisseur: Lenz Laborglas GmbH & CO.KG

Description: Support, complete with clamps and connectors

Numéro de catalogue: (BOSSBS-2752R-A750)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Numéro de catalogue: (531-1000)

Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Transfer tubing, Tubing int.Ø: 0,5 mm, Tubing ext.Ø: 6,5 mm

UOM: 1 * 1 ST

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Numéro de catalogue: (BOSSBS-2752R-A555)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Agitateurs, Magnetic Hotplate Stirrer

Numéro de catalogue: (BOSSBS-2752R-A680)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Fournisseur: THARMAC GmbH

Description: Fume hood with activated charcoal filter, Cellstain®

Fournisseur: Lenz Laborglas GmbH & CO.KG

Description: Gas distribution tubes with lateral ring made of borosilicate glass 3,3.

Fournisseur: THARMAC GmbH

Description: Centrifugeuse de paillasse, Cellclip for CytoCentrifuge

Numéro de catalogue: (BOSSBS-2752R-HRP)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-2752R-FITC)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Fournisseur: Lenz Laborglas GmbH & CO.KG

Description: Stainless steel.