Votre recherche pour: WLD-TEC+GmbH

8 565 les résultats ont été trouvés

Affiner les résultats Trier par

Sort Results

Vue liste Vue simple

Comparer(0) Effacer

Évaluez le résultat de cette recherche

Accessories for Cellstain®

Fournisseur: THARMAC GmbH

Description: Charcoal filter for fume hoods, Cellstain®

Verrerie et accessoires pour évaporateurs rotatifs, Laborota 4000/4001

Fournisseur: Heidolph Instruments GmbH & Co.KG

Description: Évaporateur, rotatif

Anti-BTK Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numéro de catalogue: (BOSSBS-2752R-A350)

Fournisseur: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promotion