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Image du produit-633-0153

Comparateurs colorimétriques, système 2000

Fournisseur: Lovibond Tintometer
Description: Disponibles pour la plupart des échelles de couleur courantes. Chaque système comprend:

Image non disponible-BOSSBS-1922R-A647

Anti-TRF2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numéro de catalogue: (BOSSBS-1922R-A647)
Fournisseur: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image non disponible-BOSSBS-1922R-A555

Anti-TRF2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Numéro de catalogue: (BOSSBS-1922R-A555)
Fournisseur: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image non disponible-BOSSBS-1922R-A350

Anti-TRF2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numéro de catalogue: (BOSSBS-1922R-A350)
Fournisseur: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image du produit-620-2425

VWR® Traceable®, Thermomètre numérique, haute précision, réfrigérateur et congélateur

Numéro de catalogue: (620-2425)
Fournisseur: VWR Collection
Description: Ce thermomètre haute précision surveille à la fois l’air ambiant et la température à l’intérieur d’un réfrigérateur ou d’un congélateur. Il lit à 0,01 °C pendant le contrôle des températures MIN/MAX en laboratoire, et dans le réfrigérateur ou le congélateur simultanément, avec la date et l’heure exactes auxquelles les lectures se sont produites. Il peut également être utilisé dans les bains-marie, blocs de chauffage et incubateurs.
UOM: 1 * 1 ST
Image du produit-620-2004

VWR® Traceable®, Thermomètre numérique à large spectre

Numéro de catalogue: (620-2004)
Fournisseur: VWR Collection
Description: Pour le contrôle qualité, la surveillance de routine, la mesure de la température dans les cuvettes, les systèmes de gaz, les réactifs, les solutions chimiques, le sol, les bains-marie, les fours, les incubateurs, les produits pétroliers, les aliments et les eaux usées. La touche de mémoire instantanée permet de retenir les valeurs minimum/maximum sur n’importe quelle période. Sonde à thermocouple de type K en acier inoxydable pour les sondes de type J, K ou T.
UOM: 1 * 1 ST
Image du produit-PRSI7343

Anti-DIS3 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI7343)
Fournisseur: ProSci Inc.
Description: DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
UOM: 1 * 1 EA
Image non disponible-BOSSBS-5221R-CY5

Anti-BRCA1 Rabbit Polyclonal Antibody (Cy5®)

Numéro de catalogue: (BOSSBS-5221R-CY5)
Fournisseur: Bioss
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM: 1 * 100 µl
Image du produit-444-2918

VWR® Advanced 10000, Agitateurs orbitaux

Fournisseur: VWR Collection
Description: Agitateurs numériques avec commande par microprocesseur, idéals pour une gamme d’applications de mélange avec des charges lourdes, par exemple, les cultures cellulaires, les études de solvabilité et les procédures d’extraction. La commande à vitesse variable assure une agitation constante et uniforme. Le système d’agitation Accu-Drive offre un contrôle de la vitesse, une précision, une sécurité et une durabilité exceptionnelles ; le système surveille en permanence la vitesse d’agitation et maintient le point de consigne même sous des charges changeantes.

Environmentally Preferable

Image non disponible-BOSSBS-5221R-A647

Anti-BRCA1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Numéro de catalogue: (BOSSBS-5221R-A647)
Fournisseur: Bioss
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM: 1 * 100 µl
Image du produit-A9742.0002

Kits de validation du thermocycleur

Numéro de catalogue: (A9742.0002)
Fournisseur: PanReac AppliChem
Description: Les faux négatifs ou les résultats PCR non spécifiques sont très critiques et pourraient être dus à un élément chauffant défectueux (élément Peltier) du thermocycleur PCR. Un contrôle de la température de réaction est donc essentiel. Le kit de validation du thermocycleur fournit une réaction PCR sensible à la température pour surveiller les incohérences dans la plage de température le thermocycleur.
UOM: 1 * 2 Tests

Certificats


Image non disponible-PRSI33-388

Anti-HLA-ABC Mouse Monoclonal Antibody [clone: 246-B8.E7]

Numéro de catalogue: (PRSI33-388)
Fournisseur: ProSci Inc.
Description: Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.
UOM: 1 * 1 EA

New Product


Image du produit-662-0940

VWR® Traceable®, Luxmètre, double affichage

Numéro de catalogue: (662-0940)
Fournisseur: VWR Collection
Description: Les doubles affichages affichent les lux ou les pieds-bougies, ou le pourcentage de différence par rapport à un point de référence, et la source de lumière sélectionnée (lumière du jour, tungstène, fluorescente ou mercure). Le luxmètre Traceable® peut être connecté à un ordinateur ou à un enregistreur de données pour surveiller et conserver les résultats. Pour garantir la précision, un certificat Traceable® avec numéro de série individuel est fourni par un laboratoire d’étalonnage certifié ISO/CEI 17025 et accrédité par A2LA. Cela certifie la traçabilité conformément aux normes du NIST (National Institute of Standards and Technology).
UOM: 1 * 1 ST
Image du produit-444-2906

VWR® Advanced 3500 Orbital Shaker

Numéro de catalogue: (444-2906)
Fournisseur: VWR Collection
Description: Agitateur numérique avec commande par microprocesseur, idéal pour une gamme d’applications de mélange, par exemple, les cultures cellulaires, les études de solvabilité et les procédures d’extraction. La commande à vitesse variable assure une agitation constante et uniforme. Le système d’agitation Accu-Drive offre un contrôle de la vitesse, une précision, une sécurité et une durabilité exceptionnelles ; le système d’agitation surveille en permanence la vitesse d’agitation et maintient le point de consigne même sous des charges changeantes.
UOM: 1 * 1 ST

Environmentally Preferable


Image non disponible-BOSSBS-7100R-A488

Anti-PNPT1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numéro de catalogue: (BOSSBS-7100R-A488)
Fournisseur: Bioss
Description: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
UOM: 1 * 100 µl
Image non disponible-BOSSBS-7100R-A350

Anti-PNPT1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numéro de catalogue: (BOSSBS-7100R-A350)
Fournisseur: Bioss
Description: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
UOM: 1 * 100 µl
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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