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Image non disponible-BOSSBS-13143R-A350

Anti-FANCM Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numéro de catalogue: (BOSSBS-13143R-A350)
Fournisseur: Bioss
Description: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.
UOM: 1 * 100 µl
Image non disponible-BNC401095-100

Anti-HLA-A Mouse Monoclonal Antibody (CF640R) [clone: 108-2C5]

Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Image non disponible-BNC941095-100

Anti-HLA-A Mouse Monoclonal Antibody (CF594) [clone: 108-2C5]

Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Image du produit-620-2426

VWR® Traceable®, Thermomètre numérique à enregistrement de données, réfrigérateur et congélateur

Numéro de catalogue: (620-2426)
Fournisseur: VWR Collection
Description: Thermomètre à enregistrement des données pouvant être utilisé dans des environnements 21 CFR 11. Parfaits pour surveiller les températures dans les réfrigérateurs, les congélateurs, les bains-marie, les blocs de chauffage et les incubateurs.
UOM: 1 * 1 ST
Image non disponible-BOSSBS-5221R-CY3

Anti-BRCA1 Rabbit Polyclonal Antibody (Cy3®)

Numéro de catalogue: (BOSSBS-5221R-CY3)
Fournisseur: Bioss
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM: 1 * 100 µl
Image non disponible-BOSSBS-5221R-A680

Anti-BRCA1 Ser1189 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numéro de catalogue: (BOSSBS-5221R-A680)
Fournisseur: Bioss
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
UOM: 1 * 100 µl
Image du produit-444-2909

VWR® Advanced 3750 Reciprocating Shaker

Numéro de catalogue: (444-2909)
Fournisseur: VWR Collection
Description: Agitateur numérique avec commande par microprocesseur, idéal pour une gamme d’applications de mélange, par exemple, les études de solvabilité et les procédures d’extraction. La commande à vitesse variable assure une agitation constante et uniforme. Le système d’agitation surveille en permanence la vitesse d’agitation et maintient le point de consigne même sous des charges changeantes.
UOM: 1 * 1 ST

Environmentally Preferable


Image du produit-620-2760

Enregistreurs de données USB multi-usages, EBI310, EBI310 TE, EBI 310 DI, EBI310 TH

Fournisseur: EBRO
Description: Ces enregistreurs de données de température faciles à utiliser, dotés d'une connexion USB, surveillent la température et/ou l'humidité pendant le transport et le stockage de produits pharmaceutiques, médicaux ou d'autres denrées périssables, le transport de médicaments, de vaccins et de produits sanguins. Ils ne nécessitent aucune interface de programmation ou d'affichage de données. Un rapport au format PDF automatique peut être généré sans aucun logiciel.

Image du produit-ERLAAS016010021

Capteur de qualité de l'air en laboratoire, Halo Sense

Fournisseur: ERLAB CAPTAIRE
Description: Halo Sense a été conçu pour surveiller en continu la qualité de l'air des laboratoires, à la recherche d'un large éventail de fumées et de vapeurs. Halo Sense est fourni en 3 versions : composés organiques volatils (COV), acide et formaldéhyde.
Please complete the quote request to enable us to assist you in finding the right unit for your application.
https://be.cmd2.vwr.com/bin/public/fc/main?f=Y5&pimid=20525804

New Product

Image non disponible-BNUM1095-50

Anti-HLA-A Mouse Monoclonal Antibody (Purified, BSA-free) [clone: 108-2C5]

Numéro de catalogue: (BNUM1095-50)
Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.
UOM: 1 * 50 µl
Image non disponible-461-0417

VWR®, Accessories for Refrigerated Circulators

Numéro de catalogue: (461-0417)
Fournisseur: VWR Collection
Description: À utiliser avec les circulateurs VWR® à contrôleur programmable ou numérique lorsque le contrôle numérique direct n’est pas requis. Se connecte au port RS232 et fournit un signal analogique de 10 mv / degré pour la surveillance ou le contrôle externe.
UOM: 1 * 1 ST
Image du produit-DOEH204706646

NBB®-B-AM, bouillon

Numéro de catalogue: (DOEH204706646)
Fournisseur: DOEHLER GROUP
Description: Milieu de culture pour la détection qualitative des microorganismes indicateurs à l'aide d'une méthode d'écouvillonnage réalisée avec des écouvillons stériles dans le cadre de la surveillance microbiologique de l'équipement. Sous sa marque NBB®, Döhler propose des milieux de culture innovants pour la détection rapide et fiable des microorganismes contaminant les boissons (par exemple, les bactéries Lactobacillus, Pectinatus et Megasphaera), et ce dans tous les échantillons provenant de brasseries, ainsi que pour l'industrie du vin. NBB®-B-AM est un milieu de culture liquide qui permet de détecter les microorganismes indicateurs de biofilms.
UOM: 1 * 20 ST

Certificats


Image non disponible-BNC471095-100

Anti-HLA-A Mouse Monoclonal Antibody (CF647) [clone: 108-2C5]

Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Image non disponible-BNUB1095-100

Anti-HLA-A Mouse Monoclonal Antibody (Purified) [clone: 108-2C5]

Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Image non disponible-BNC881095-500

Anti-HLA-A Mouse Monoclonal Antibody (CF488A) [clone: 108-2C5]

Fournisseur: Biotium
Description: HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the α1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the α1 domain was demonstrated in the formation of an intralocus HLA-A determinant.

Image non disponible-BOSSBS-8444R-A750

Anti-BRCA1Ser988 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Numéro de catalogue: (BOSSBS-8444R-A750)
Fournisseur: Bioss
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localisation and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
UOM: 1 * 100 µl
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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