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Image non disponible-BOSSBS-1370R-A555

Anti-ATM Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Description: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Numéro de catalogue: BOSSBS-1370R-A555
UOM: 1 * 100 µl
Fournisseur: Bioss
Image non disponible-BOSSBS-5130R-A488

Anti-PRKDC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Description: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
Numéro de catalogue: BOSSBS-5130R-A488
UOM: 1 * 100 µl
Fournisseur: Bioss
Image du produit-118-0317

Gas detection tubes for benzene

Description: To measure the 'spot concentrations' of carbon dioxide for use with an Accuro® pump. Uses include determination and measurement of concentration peaks, personal exposure in the inhalation area, detection of leaks in pipelines or gas installations, air analysis in sewers, shafts and confined spaces.
Numéro de catalogue: 118-0317
UOM: 1 * 10 ST
Fournisseur: Dräger
Image du produit-151-0160

Tubes de détection de gaz, mercaptans

Description: Pour la mesure des « concentrations ponctuelles » de mercaptan. Les applications incluent la détermination et la mesure des pics de concentration, la mesure de l'exposition personnelle dans la zone d'inhalation, la détection des fuites, par exemple dans les pipelines ou les installations gazières, et l'analyse de l'air dans les orifices d'évacuation, les tiges et les espaces confinés.
Numéro de catalogue: 151-0160
UOM: 1 * 10 ST
Fournisseur: Dräger
Image du produit-466-0373

Étuves de chauffage et de séchage, Universal UN/UNplus (convection naturelle)

Description: La gamme comporte des modèles à convection naturelle ayant une plage de température allant jusqu'à 300 °C. Deux écrans au choix : SingleDISPLAY ou TwinDISPLAY selon l'application.
Numéro de catalogue: 466-0373
UOM: 1 * 1 ST
Fournisseur: MEMMERT
Image du produit-118-0313

Tubes de détection de gaz, court terme pour pompe Accuro, toluène

Description: Pour la mesure des « concentrations ponctuelles » du toluène. Les utilisations comprennent la détermination et la mesure des pics de concentration, la mesure de l'exposition personnelle dans la zone d'inhalation, la détection des fuites, par exemple dans les pipelines ou les installations gazières, et l'analyse de l'air dans les orifices d'évacuation, les tiges et les espaces confinés.
Numéro de catalogue: 118-0313
UOM: 1 * 10 ST
Fournisseur: Dräger
Image du produit-BIND8012-1134

Accessories for drying ovens with natural convection ED series, Avantgarde.Line

Description: Accessories for drying ovens with natural convection ED series, Avantgarde.Line
Numéro de catalogue: BIND8012-1134
UOM: 1 * 1 ST
Fournisseur: Binder
Image du produit-NABE699000279

Accessories for high-temperature furnaces

Description: Accessories for high-temperature furnaces
Numéro de catalogue: NABE699000279
UOM: 1 * 1 ST
Fournisseur: NABERTHERM
Image non disponible-BOSSBS-1370R-CY3

Anti-ATM Rabbit Polyclonal Antibody (Cy3®)

Description: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Numéro de catalogue: BOSSBS-1370R-CY3
UOM: 1 * 100 µl
Fournisseur: Bioss
Image non disponible-BOSSBS-1370R-CY7

Anti-ATM Rabbit Polyclonal Antibody (Cy7®)

Description: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Numéro de catalogue: BOSSBS-1370R-CY7
UOM: 1 * 100 µl
Fournisseur: Bioss
Image non disponible-BOSSBS-1370R-A647

Anti-ATM Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Description: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. recognises the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Numéro de catalogue: BOSSBS-1370R-A647
UOM: 1 * 100 µl
Fournisseur: Bioss
Image non disponible-BOSSBS-5130R-CY7

Anti-PRKDC Rabbit Polyclonal Antibody (Cy7®)

Description: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
Numéro de catalogue: BOSSBS-5130R-CY7
UOM: 1 * 100 µl
Fournisseur: Bioss
Image non disponible-BOSSBS-5130R-HRP

Anti-PRKDC Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Description: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
Numéro de catalogue: BOSSBS-5130R-HRP
UOM: 1 * 100 µl
Fournisseur: Bioss
Image du produit-151-3154

Gas detection tube for formaldehyde

Description: <B>Cross sensitivity:</B> Styrene, vinyl acetate, acetaldehyde, acrolein, diesel fuel and furfuryl alcohol are indicated with a yellowish brown discoloration. 500 ppm octane, 5 ppm nitric oxide and 5 ppm nitrogen dioxide have no effect.
Numéro de catalogue: 151-3154
UOM: 1 * 10 ST
Fournisseur: Dräger
Image non disponible-NEOL2-2561

Top-Rack Tripods

Description: <p>Colour top-rack tripods, 80 seats</p>
Numéro de catalogue: NEOL2-2561
UOM: 1 * 1 ST
Fournisseur: NEOLAB

New Product


Image non disponible-NEOL2-2575

Combi-Rack for Test Tubes

Description: <p>Combi rack for test tubes, 96-position.</p>
Numéro de catalogue: NEOL2-2575
UOM: 1 * 1 ST
Fournisseur: NEOLAB

New Product


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