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HPV16 (E7) Peptide Pool

Numéro de catalogue: (STMC100-1394)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with HPV16 (E7) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (E7) Peptide pool is a lyophilised mixture of 22 peptides from protein E7 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 98 on protein E7. E7 is an oncoprotein that binds and mediates degradation of the retinoblastoma tumor suppressor protein pRB (Gonzalez <i>et al.</i>). E7 together with E6 demonstrated the ability to immortalize human keratinocytes in vitro, which likely has significance for HPVs oncogenic potential (Hawley-Nelson <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

New Product

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Conductimètres/°C de paillasse, inoLab® Cond 7110/7310

Fournisseur: WTW
Description: Conductimètres avec technologie de mesure avancée qui rendent les mesures pratiques et fiables.

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Tamis cellulaires, Falcon®

Fournisseur: Corning
Description: Un moyen fiable, simple et prêt-à-l'emploi d'obtenir une suspension cellulaire plus homogène. Membrane en nylon (différentes porosités disponibles: 40, 70 ou 100 µm), permettant de nombreuses applications. Alternative plus rapide et plus facile que la filtration sur gaze pour la dissociation d'amas de cellules ou de cultures primaires.

Certificats

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di-Sodium tétraborate, anhydre pour analyses, Supelco®

Fournisseur: Merck
Description: Pour obtenir des informations complètes sur les spécifications et les dangers, consultez le site www.vwr.com ou les catalogues de produits chimiques VWR

MSMD

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Candida (MP65) Peptide Pool

Numéro de catalogue: (STMC100-1407)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with Candida (MP65) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. Candida peptide pool is a lyophilised mixture of 92 peptides from the mannoprotein MP65 of Candida albicans (yeast), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 379 on MP65. MP65 contributes to cell wall integrity and epithelia adherence (Sandini <i>et al.</i>), and is a potent T cell immunogen (Gomez <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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HHV1 (gD) Peptide Pool

Numéro de catalogue: (STMC100-1406)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with HHV1 (gD) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV1 (gD) Peptide pool is a lyophilised mixture of 96 peptides from envelope glycoprotein D of human herpesvirus 1 (HHV1; strain Patton), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 394 on gD. gD is required at the first stage of virus-induced membrane fusion (Subramanian and Geraghty), which likely occurs via binding to receptors such as nectin-1 (Giovine <i>et al.</i>) and HVEM (Connolly <i>et al.</i>) on cell surfaces. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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Balances de table multifonctions à montage frontal, Defender 5000

Fournisseur: OHAUS
Description: Les balances de table multifonctions de la série Defender 5000 sont idéales pour de nombreuses applications, notamment la production, l'emballage, l'inventaire et l'expédition. Construites de manière durable pour résister aux environnements difficiles et équipées d'une plate-forme en acier inoxydable, d'un cadre en acier inoxydable et d'une cellule de charge en acier inoxydable (modèles à plage unique) ou en aluminium (modèles à double plage). L'indicateur D52XW monté à l'avant est en acier inoxydable 304 avec traitement de surface sablé, qui offre une protection IP 68.

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CMV (IE1) Peptide Pool

Numéro de catalogue: (STMC100-1413)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with CMV (IE-1) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV (IE-1) peptide pool is a lyophilised mixture of 120 peptides from the immediate early protein IE1 (IE1) of human cytomegalovirus (CMV; strain AD169), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 491 on IE1. CMV IE1 is a transcriptional transactivator and autoregulator (Cherrington and Mocarski). Studies show that IE1 promotes viral transcription by antagonizing histone deacetylation (Nevels <i>et al.</i>) and, along with IE2, may contribute to the survival of CMV-infected cells by blocking tumor necrosis factor alpha (TNF-α)-induced apoptosis (Zhu <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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JCV (VP1) Peptide Pool

Numéro de catalogue: (STMC100-1400)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with JCV (VP1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 86 peptides from major capsid protein VP1 (VP1) of the JC polyomavirus (JCV), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 354 on VP1. VP1 binds LSTc oligosaccharides found on host cell glycoproteins and glycolipids, and this interaction is said to be essential for JCV viral growth and infectivity (Neu <i>et al.</i>). The JCV VP1 (Del Valle <i>et al.</i>) and large T antigen (LT) (Delbue <i>et al.</i>) are detected in JCV-associated pathologies such as progressive multifocal leukoencephalopathy (PML) in patients with HIV. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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EBV (EBNA-3B) Peptide Pool

Numéro de catalogue: (STMC100-1387)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with EBV (EBNA-3B) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (EBNA-3B) Peptide Pool is a lyophilised mixture of 234 peptides from Epstein-Barr nuclear antigen 3B (EBNA-3B) of Epstein-Barr virus (EBV; strain AG876) and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 946 on EBNA-3B. EBNA-3B is considered non-essential for B cell growth transformation (Chen <i>et al.</i>, 2005; Tomkinson and Kieff), but has been shown to regulate the expression of cellular genes in EBV-infected cells (Chen at al., 2006). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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HPV16 (L1) Peptide Pool

Numéro de catalogue: (STMC100-1392)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with HPV16 (L1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (L1) Peptide pool is a lyophilised mixture of 124 peptides from major capsid protein L1 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 505 on L1. L1 enters the nuclei of host cells via a Kap α2β1-mediated pathway (Nelson <i>et al.</i>). It cooperates with E2, another viral protein, to enhance viral DNA replication (Siddiqa <i>et al.</i>). L1 pentamers can assemble into virus-like particles (Chen <i>et al.</i> 2000; Chen <i>et al.</i> 2001). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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VWR®, Cartouches d’extraction, grade 501

Fournisseur: VWR Collection
Description: Pure cellulose de coton. Conviennent à tout type d’extracteur (Soxhlet, Büchi, Gerhardt, etc.).

Image du produit-STMC100-1412

CMV (IE2) Peptide Pool

Numéro de catalogue: (STMC100-1412)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with CMV (IE-2) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV (IE-2) Peptide pool is a lyophilised mixture of 143 peptides from immediate early protein 2 (IE2) of human cytomegalovirus (CMV; strain AD169), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 580 on IE2. IE2 is critical for viral infection and for the expression of CMV early genes (Marchini <i>et al.</i>). It also controls transcription initiation for a subset of early-late and late viral promoters via RNA polymerase II (Li <i>et al.</i>). IE2, along with IE1, may contribute to the survival of CMV-infected cells by blocking tumor necrosis factor alpha (TNF-α)-induced apoptosis (Zhu <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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SARS-CoV-2 (Spike Protein) Omicron BA.4/BA.5 Peptide Pool

Numéro de catalogue: (STMC100-1421)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron BA.4/BA.5 Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This pool is provided as two lyophilised mixtures (subpools) from the spike glycoprotein of SARS-CoV-2 Omicron BA.4/BA.5 subvariant. The subpools contain 158 and 157 peptides, respectively, for a total of 315 peptides, and they consist of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 1270 on the spike protein. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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Image du produit-STMC100-1395

HPV16 (E6) Peptide Pool

Numéro de catalogue: (STMC100-1395)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with HPV16 (E6) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (E6) Peptide Pool is a lyophilised mixture of 37 peptides from the E6 protein of human papillomavirus type 16 (HPV16). The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 158 on protein E6. E6 binds to the tumor suppressor protein p53 and stimulates its degradation (Scheffner <i>et al.</i>; Werness <i>et al.</i> ), which is thought to cause an increase in spontaneous mutagenesis in host cells (Havre <i>et al.</i>). E6 together with E7 demonstrated the ability to immortalize human keratinocytes in vitro, which likely has significance for HPVs oncogenic potential (Hawley-Nelson <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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Image du produit-STMC100-1399

JCV (LT) Peptide Pool

Numéro de catalogue: (STMC100-1399)
Fournisseur: STEMCELL Technologies
Description: Stimulating T cells with JCV (LT) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 170 peptides from large T antigen (LT) of JC polyomavirus (JCV), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 688 on LT. LT is detectable during JCV latency (Rossi <i>et al.</i>), and in immunocompromised patients with JVC-associated pathologies such as progressive multifocal leukoencephalopathy (PML) (Delbue <i>et al.</i>). In PML, LT has been associated with activating the promoter of survivin, an anti-apoptotic protein (Del Valle <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM: 1 * 1 UO

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