Votre recherche pour: Mat\u00E9riel+d\'urgence

Numéro de catalogue: (BOSSBS-4004R-A488)

Fournisseur: Bioss

Description: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

UOM: 1 * 100 µl

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Numéro de catalogue: (PRSI6465)

Fournisseur: ProSci Inc.

Description: FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (PRSI5405)

Fournisseur: ProSci Inc.

Description: SKA3 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Like with SKA1 or SKA2, depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged a metaphase-like state. These SKA3-depleted cells accumulate high levels of the checkpoint protein Bub1 at kinetochores, suggesting the SKA complex plays a key role in spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (PRSI5401)

Fournisseur: ProSci Inc.

Description: SKA1 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (LANC01060178)

Fournisseur: GETINGE LIFE SCIENCES

Description: BOUTON ARRET D'URGENCE 1 * 1 Pce

UOM: 1 * 1 ST

Promotion

Numéro de catalogue: (PRSI28-718)

Fournisseur: ProSci Inc.

Description: FXYD5 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIon Channel (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIon Channel) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (PRSI28-255)

Fournisseur: ProSci Inc.

Description: FXYD5 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein.This reference sequence was derived from AF161462.1 and ESTs; validated by multiple replicate ESTs and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (PRSI5403)

Fournisseur: ProSci Inc.

Description: SKA2 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

UOM: 1 * 1 EA

Promotion

Numéro de catalogue: (LANCP90010454)

Fournisseur: GETINGE LIFE SCIENCES

Description: ARRET D'URGENCE 1400 LX-LXP 1 * 1 Pce

UOM: 1 * 1 ST

Promotion

Numéro de catalogue: (BELI820822)

Fournisseur: BELIMED

Description: Bouton arret d'urgence cote propre 1 * 1 Pce

UOM: 1 * 1 ST

Promotion

Fournisseur: Plum Safety

Description: Sac en bandoulière pour flacons de solution de lavage oculaire 200 ml, Pour: Plum, Station de douche oculaire

Numéro de catalogue: (139-0806)

Fournisseur: VWR Collection

Description: Laboratory safety showers should be tested once a month to check the functionality and the required water flow rate of 60 L/min. for emergency instances. This mobile test unit provides a very convenient and easy solution to test both body safety showers and handheld eye showers.

UOM: 1 * 1 ST

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Numéro de catalogue: (ROTH0195.1)

Fournisseur: Roth Carl

Description: Insulating mat 1 * 10 m

UOM: 1 * 10 m

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 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.

Numéro de catalogue: (BURK2507-2001)

Fournisseur: BURKLE

Description: Wall fixture for mini eyewash station

UOM: 1 * 1 ST

Promotion

Numéro de catalogue: (IKAA20008398)

Fournisseur: IKA

Description: Rubber mat 1 * 1 Pce

UOM: 1 * 1 ST

Promotion

Numéro de catalogue: (BROE17.160.009)

Fournisseur: BROEN-LAB

Description: Wall recessed eye shower with anti-corrosive cabinet.

UOM: 1 * 1 ST

Promotion