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Image du produit-PRSI48-680

Anti-RIF1 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI48-680)
Fournisseur: ProSci Inc.
Description: Rif1 (also known as telomere-associated protein RIF1 and Rap1-interacting factor 1) is a mouse ortholog of the yeast Rif1 family of telomere-associated proteins identified on the basis of its high expression in primordial germ cells and embryo-derived pluripotent stem cell lines. Mouse Rif1 is a protein involved in negative regulation of telomere length. It is also localized to ATM dependent DNA damage foci and may act at the chromatin level to allow access to some factors.
UOM: 1 * 50 µG
Image non disponible-PRSI33-174

Anti-MCAM Mouse Monoclonal Antibody [clone: OJ79c]

Numéro de catalogue: (PRSI33-174)
Fournisseur: ProSci Inc.
Description: The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18/CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
UOM: 1 * 1 EA

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Image non disponible-PRSI92-061

Human recombinant METAP1D (from E. coli)

Numéro de catalogue: (PRSI92-061)
Fournisseur: ProSci Inc.
Description: Methionine Aminopeptidase 1D (METAP1D) is a mitochondrion protein that belongs to the peptidase M24A family. METAP1D is overexpressed at the protein level in colon cancer cell lines and colon tumors as compared to normal tissues. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. METAP1D is also active with zinc, manganese or divalent ions. It may also play an important role in colon tumorigenesis.
UOM: 1 * 50 µG
Image du produit-PRSI55-642

Anti-CTSZ Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI55-642)
Fournisseur: ProSci Inc.
Description: The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
UOM: 1 * 400 µl

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Image du produit-PRSIXW-7955

Anti-LSM1 Chicken Polyclonal Antibody

Numéro de catalogue: (PRSIXW-7955)
Fournisseur: ProSci Inc.
Description: FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
SUBUNIT: LSm subunits form a heteromer with a dougnut shape.
SIMILARITY: Belongs to the snRNP Sm proteins family.
SUBCELLULAR LOCATION: Nuclear (Potential).
TISSUE SPECIFICITY: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.
UOM: 1 * 50 µG
Image du produit-PRSI4615

Anti-UROP11 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI4615)
Fournisseur: ProSci Inc.
Description: UROP11 Antibody: Upregulated obese product 11 (UROP11) was isolated from subtractive library for mouse hypothalamus. It is detected in numerous tissues and is upregulated in the hypothalamus and adipocytes in obese mice. UROP11 is also observed in human neural and lymphoid tissues; its expression appears to be regulated by the level of lymphoid activation. Urop11 expression is strongly upregulated both in vivo in mouse hypothalamus and in vitro in mouse neural cell lines after treatment with leptin, indicating Urop11 is a target of leptin activity and thus may play a role in obesity.
UOM: 1 * 1 EA
Image du produit-PRSI55-915

Anti-DNTT Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI55-915)
Fournisseur: ProSci Inc.
Description: This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
UOM: 1 * 400 µl

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Image non disponible-PRSI92-432

Human recombinant GDNF Receptor alpha 2 (from cells)

Numéro de catalogue: (PRSI92-432)
Fournisseur: ProSci Inc.
Description: GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signalling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
UOM: 1 * 50 µG
Image non disponible-PRSI33-629

Anti-CD28 Mouse Monoclonal Antibody [clone: C28/1636]

Numéro de catalogue: (PRSI33-629)
Fournisseur: ProSci Inc.
Description: CD28 is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
UOM: 1 * 1 EA

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Image non disponible-PRSI96-482

Human recombinant JAG1 (from HEK293 cells)

Numéro de catalogue: (PRSI96-482)
Fournisseur: ProSci Inc.
Description: Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
UOM: 1 * 50 µG
Image non disponible-PRSI34-036

Anti-PLIN2 Mouse Monoclonal Antibody [clone: ADPN1-1]

Numéro de catalogue: (PRSI34-036)
Fournisseur: ProSci Inc.
Description: Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material and maybe involved in development and maintenance of adipose tissue. It is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
UOM: 1 * 1 EA

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Image du produit-PRSI4779

Anti-IL34 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI4779)
Fournisseur: ProSci Inc.
Description: IL-34 Antibody: Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.
UOM: 1 * 1 EA
Image du produit-PRSI3779

Anti-ACTB Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI3779)
Fournisseur: ProSci Inc.
Description: Beta-actin Antibody: Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
UOM: 1 * 1 EA
Image non disponible-PRSI92-151

Human recombinant NCR3

Numéro de catalogue: (PRSI92-151)
Fournisseur: ProSci Inc.
Description: Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumour cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signalling specifically induces lytic activity against several tumour cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
UOM: 1 * 50 µG
Image non disponible-PRSI91-308

Human recombinant CAR (from Cells)

Numéro de catalogue: (PRSI91-308)
Fournisseur: ProSci Inc.
Description: Coxsackievirus and Adenovirus Receptor (CAR) belongs to the CTX family of the Ig superfamily. CXADR is a type I transmembrane glycoprotein and expressed in pancreas, brain, heart, small intestine, testis, prostate. It is a receptor that mediates gene transfer and also act as an adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs. CXADR contains an extracellular domain, a transmembrane helix and a C-terminal intracellular domain. The C-terminal interacts with few cytoplasmic junctional proteins, microtubules and the actin cytoskeleton.
UOM: 1 * 50 µG
Image du produit-PRSIXP-5234BT

Anti-CCL3 Rabbit Polyclonal Antibody (Biotin)

Numéro de catalogue: (PRSIXP-5234BT)
Fournisseur: ProSci Inc.
Description: MIP1 alpha and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation.
UOM: 1 * 50 µG
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