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Ribitol, poudre blanche

Fournisseur: MP Biomedicals
Description: Adonitol (ribitol), a pentose alcohol, is metabolised to teicholic acids used in the cell walls of gram positive bacteria. Adonitol is often compared to other cell permeating molecules such as formamide, propanediol, and DMSO as a cryopreservation agent.

Image non disponible-ICNA0219032725

Chlortétracycline chlorhydrate, 900 u/mg, poudre jaune

Fournisseur: MP Biomedicals
Description: Chlortetracycline hydrochloride has antimicrobial action similar to tetracycline hydrochloride, but it is somewhat less active against many Gram-negative organisms. It was first isolated from the culture of <i>Streptomyces aureofacien</i>.

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Streptomycine sulfate USP, Qualité Biologie Moléculaire

Fournisseur: G-Biosciences
Description: Mode of action and anti-microbial spectrum streptomycin sulphate is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. It binds to the #12 protein on the ribosomal 30S subunit and inhibits protein synthesis.

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Kanamycine sulfate ∼735 μg/mg (de Streptomyces kanamyceticus), poudre blanche

Fournisseur: MP Biomedicals
Description: Kanamycin Monosulfate is an aminoglycoside bacteriocidal antibiotic which acts as an inhibitor of protein biosynthesis by producing a misreading of the 70s-ribosome.
Kanamycin Monosulfate used in biotechnology applications to inhibit protein synthesis. It is also used as a selection agent for cells transformed with kanamycin B (neoR, kanR) resistance gene.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.

Certificats

Image du produit-PRSI3649

Anti-TLR5 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI3649)
Fournisseur: ProSci Inc.
Description: TLR5 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappa B, leading to the activation of TNF-alpha and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires'disease and demonstrates the importance of TLR5 in the innate immune response.
UOM: 1 * 1 EA
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Paromomycin sulphate ≥97%, en poudre

Numéro de catalogue: (ICNA0215605625)
Fournisseur: MP Biomedicals
Description: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has <i>in vitro</i> and <i>in vivo</i> activity similar to neomycin. It is effective against gram-negative bacteria, gram-positive bacteria, some protozoan species, and limited anti helminth. It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit cryptosporidium infection of a human enterocyte cell line.
UOM: 1 * 25 g
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Polymyxine B, sulfate

Fournisseur: MP Biomedicals
Description: Polymyxin B sulphate is a mixture of Polymyxin B1 and Polymyxin B2 sulphate, obtained from Bacillus polymyxia strains. Polymyxin B inhibits gram-negative organisms<i> in vitro</i> wherein it binds to and interferes with the permeability of the bacterial cytoplasmic membrane and is also reported to inhibit Ca<sup>2+</sup> dependent protein kinase C (PKC). Effective concentration is typically 50 mg/l.

Image du produit-HEWL419910-301

Colonnes préparatives LC

Fournisseur: Agilent
Description: These Prep LC columns are designed for high loadability to purify milligram to gram quantities of products.

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Cetrimonium bromure ≥98% pour la biologie moléculaire

Fournisseur: MP Biomedicals
Description: Cetyltrimethylammonium bromide is a phase transfer catalyst ideal for the precipitation of DNA. Hexadecyltrimethylammonium bromide is a bactericidal, cationic detergent. Its activity is neutralized by soaps and anionic detergents (i.e., SDS). Trimethylammonium bromide compounds form insoluble complexes with SDS. It is active at alkaline pH against both Gram positive and Gram negative organisms.

Cetyltrimethylammonium bromide ia used as an cationic surfactant suitable for the isolation of high molecular weight DNA in plants and other organisms(by a rapid method) as well as plant DNA for use in PCR analysis. It has been used to precipitate nucleic acids. CTAB provides enhancement of Concanavalin A mediated agglutination. It has been used for the determination of protein molecular weights in electrophoretic systems and for determination of critical micelle concentration of detergents. CTAB has also been used as a titrant for potentiometric titration of perchlorate and as a phase-transfer catalyst in reduction of arenes and heterocyclic compounds.

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Anti-PI3 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI26-045)
Fournisseur: ProSci Inc.
Description: PI3 is an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. PI3 contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. PI3 belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM: 1 * 50 µG
Image non disponible-PRSI92-658

K. pneumoniae Recombinant Kanamycin kinase type II (from E. coli)

Numéro de catalogue: (PRSI92-658)
Fournisseur: ProSci Inc.
Description: Aminoglycoside 3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH(3') is primarily found in certain species of gram-positive bacteria.
UOM: 1 * 50 µG
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Anti impact gloves, Aqua-Seal Pro A726

Fournisseur: Portwest
Description: The Aqua-Seal Pro is 100% waterproof and offers comprehensive protection for the hand against multiple hazards. TPR protective pods across the back of the hand provides protection against impact risks to the hand. A 100 gram Insulated lining gives excellent thermal insulation properties.

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Tobramycine

Fournisseur: MP Biomedicals
Description: Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius and used to treat various types of bacteria infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It works by binding to a site on bacterial 30S and 50S ribosome, preventing formation of the 70S complex. As a result, mRNA cannot be translated into protein and cell death ensues. Tobramycin is preferred over gentamicin for Pseudomonas aeruginosa pneumonia due to better lung penetration.

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Human recombinant WW domain-binding 2 (from E. coli)

Numéro de catalogue: (PRSI91-988)
Fournisseur: ProSci Inc.
Description: WW Domain-Binding Protein 2 (WBP2) is a ubiquitous protein that contains one GRAM domain. The WW domain is composed of 38 to 40 semi-conserved AA shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is participated in mediating protein-protein interactions. WBP2 binds to the WW domain of YAP1, WWP1 and WWP2. The WW-binding 1 motif of WBP2 mediates interaction with NEDD4. The function of this protein WBP2 has not been determined. Some researches demonstrate that WBP-2 also interacts with the thyroid-specific transcription factor Pax8.
UOM: 1 * 50 µG
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Anti-TLR4 Rabbit Polyclonal Antibody

Numéro de catalogue: (PRSI3141)
Fournisseur: ProSci Inc.
Description: TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
UOM: 1 * 1 EA
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Aztreonam, poudre blanche

Fournisseur: MP Biomedicals
Description: Aztreonam is the first totally synthetic monocyclic β-lactam antibiotic that displays a high degree of resistance to β-lactamase degradation. It has high specificity for gram-negative aerobic rods.

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