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Image du produit-25-1276-U100

Anti-Ly-6G Rat Monoclonal Antibody (APC (Allophycocyanin))/Cy7®) [clone: 1A8]

Numéro de catalogue: (25-1276-U100)
Fournisseur: Tonbo Biosciences
Description: The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
UOM: 1 * 1 EA
Image du produit-65-1886-U100

Anti-CD8A Rat Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: 2.43]

Numéro de catalogue: (65-1886-U100)
Fournisseur: Tonbo Biosciences
Description: The 2.43 antibody reacts with the 32 to 34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death in tumor cells, as well as in cells infected by virus, bacteria or parasites.
UOM: 1 * 1 EA
Image du produit-35-1152-U100

Anti-CSF1R Rat Monoclonal Antibody (FITC (Fluorescein)) [clone: AFS98]

Numéro de catalogue: (35-1152-U100)
Fournisseur: Tonbo Biosciences
Description: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerisation of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.
UOM: 1 * 1 EA
Image du produit-65-4301-U100

Rat IgG1 Isotype Control [clone: HRPN] (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®)

Numéro de catalogue: (65-4301-U100)
Fournisseur: Tonbo Biosciences
Description: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.
UOM: 1 * 1 EA
Image non disponible-65-4031-U100

Rat IgG2b Isotype Control [clone: LTF-2] (PerCP (Peridinin-Chlorophyll Protein Complex)/Cy5.5®)

Numéro de catalogue: (65-4031-U100)
Fournisseur: Tonbo Biosciences
Description: The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.
UOM: 1 * 1 EA
Image non disponible-55-0041-U100

Anti-CD4 Rat Monoclonal Antibody (PE (Phycoerythrin)/Cy5®) [clone: GK1.5]

Numéro de catalogue: (55-0041-U100)
Fournisseur: Tonbo Biosciences
Description: The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells
UOM: 1 * 1 EA
Image non disponible-75-4031-U100

Rat IgG2b Isotype Control [clone: LTF-2] (violetFluor® 450)

Numéro de catalogue: (75-4031-U100)
Fournisseur: Tonbo Biosciences
Description: The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.
UOM: 1 * 1 EA
Image non disponible-70-5893-U100

Anti-KLRG1 Mouse Monoclonal Antibody [clone: 2F1]

Numéro de catalogue: (70-5893-U100)
Fournisseur: Tonbo Biosciences
Description: The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).
UOM: 1 * 1 EA
Image du produit-80-0032-U100

Anti-CD3 Rat Antibody (redFluor™ 710) [clone: 17A2]

Numéro de catalogue: (80-0032-U100)
Fournisseur: Tonbo Biosciences
Description: The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
UOM: 1 * 1 EA
Image du produit-80-0441-U100

Anti-CD44 Rat Monoclonal Antibody (redFluor™ 710) [clone: IM7]

Numéro de catalogue: (80-0441-U100)
Fournisseur: Tonbo Biosciences
Description: The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or “standard” form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.
UOM: 1 * 1 EA
Image non disponible-80-5931-U100

Anti-Ly-6G (Gr-1) Rat Antibody (redFluor™ 710) [clone: RB6-8C5]

Numéro de catalogue: (80-5931-U100)
Fournisseur: Tonbo Biosciences
Description: The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
UOM: 1 * 1 EA
Image du produit-80-0114-U100

Anti-CD11c Armenian Hamster Antibody (redFluor™ 710) [clone: N418]

Numéro de catalogue: (80-0114-U100)
Fournisseur: Tonbo Biosciences
Description: The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
UOM: 1 * 1 EA
Image du produit-30-0251-U100

Anti-CD25 Rat Monoclonal Antibody (Biotin) [clone: PC61.5]

Numéro de catalogue: (30-0251-U100)
Fournisseur: Tonbo Biosciences
Description: The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used to distinguish Treg cells from native or conventional T cells which are CD25-. This clone has also been reported for depletion of Treg cells in vivo (use format suitable for functional assays).
UOM: 1 * 1 EA
Image du produit-30-0441-U100

Anti-CD44 Rat Monoclonal Antibody (Biotin) [clone: IM7]

Numéro de catalogue: (30-0441-U100)
Fournisseur: Tonbo Biosciences
Description: The IM7 antibody recognises CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organisation, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or 'standard' form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion.
UOM: 1 * 1 EA
Image du produit-70-0039-U100

Anti-CD3 Mouse Monoclonal Antibody [clone: Hit3a]

Numéro de catalogue: (70-0039-U100)
Fournisseur: Tonbo Biosciences
Description: The Hit3a antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
UOM: 1 * 1 EA
Image du produit-30-0041-U100

Anti-CD4 Rat Monoclonal Antibody (Biotin) [clone: GK1.5]

Numéro de catalogue: (30-0041-U100)
Fournisseur: Tonbo Biosciences
Description: The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will "compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
UOM: 1 * 1 EA
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