Votre recherche pour: DEUTSCH+NEUMANN

Numéro de catalogue: (BOSSBS-5040R-A680)

Fournisseur: Bioss

Description: Involved in bile acid metabolism. In liver hepatocytes catalyses the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyse the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyses the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

UOM: 1 * 100 µl

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Numéro de catalogue: (PRSI27-711)

Fournisseur: ProSci Inc.

Description: Stearoyl-CoA desaturase ( fatty acid desaturase, SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These monounsaturated fatty acids are the major components of phospholipids, triglycerides, wax esters, and cholesterol esters.

UOM: 1 * 1 EA

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Fournisseur: Thermo Fisher Scientific

Description: Acide N-(acétamido-2)-amino-2-éthanesulfonique (ACES) 99+% pour biochimie

MSMD

Numéro de catalogue: (PRSI36-230)

Fournisseur: ProSci Inc.

Description: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The enzyme is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. Several SCD isoforms (SCD1, -2, and -3) exist in the mouse. Mice with a targeted disruption of the SCD1 isoform had reduced body adiposity, increased insulin sensitivity, and resistance to diet-induced weight gain. The protection from obesity involved increased energy expenditure and increased oxygen consumption. SCD1 deficiency shows activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.

UOM: 1 * 1 EA

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Numéro de catalogue: (PRSI56-815)

Fournisseur: ProSci Inc.

Description: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).

UOM: 1 * 400 µl

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Fournisseur: MP Biomedicals

Description: Applications
Taurocholic Acid Sodium Salt is an anionic detergent used for protein solubilization.
Product Description
Taurocholic Acid Sodium Salt is the conjugation product of cholic acid with taurine and the principal constituent of the bile of carnivorous animals.
Biochem/physiol Actions
Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.

Melting Point: 230 °C (decomposes)(Lit.)
Presentation: White Powder
Format: Powder
pH: 6 - 7.5(1% aq soln)
Aggregation Number: 4
Critical Micelle Concentration (CMC): 3-11 mM
Heavy Metals: =20 ppm
Loss on Drying: =7.0%
NOTES: Sodium Cholate : =3.0%
Solubility: Soluble in water (100 mg/mL).
Storage & Handling: Store at Room Temperature (15-30 °C).

Numéro de catalogue: (PRSI4571)

Fournisseur: ProSci Inc.

Description: ELOVL6 Antibody: Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.

UOM: 1 * 1 EA

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Fournisseur: MP Biomedicals

Description: Cholic acid is a biochemical solubilizing agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.

Numéro de catalogue: (8.08616.9025)

Fournisseur: Merck

Description: TAURINE POUR LA SYNTHESE 1 * 25 kg

UOM: 1 * 25 kg

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Numéro de catalogue: (90844-100MG)

Fournisseur: Merck

Description: 1-STEAROYL-RAC-GLYCEROL 1 * 100 mg

UOM: 1 * 100 mg

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Numéro de catalogue: (ABCAAB141063-1)

Fournisseur: Abcam

Description: TAURINE 1 * 1 g

UOM: 1 * 1 g

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Numéro de catalogue: (CAYM10009864-5)

Fournisseur: Cayman Chemical

Description: 1-STEAROYL-2-ARACHIDONOYL PC 1 * 5 mg

UOM: 1 * 5 mg

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Numéro de catalogue: (CAYM10009864-10)

Fournisseur: Cayman Chemical

Description: 1-STEAROYL-2-ARACHIDONOYL PC 1 * 10 mg

UOM: 1 * 10 mg

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Numéro de catalogue: (CAYM9000631-5)

Fournisseur: Cayman Chemical

Description: STEAROYL SEROTONIN 1 * 5 mg

UOM: 1 * 5 mg

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Numéro de catalogue: (CAYM90245-5)

Fournisseur: Cayman Chemical

Description: STEAROYL ETHANOLAMIDE 1 * 5 mg

UOM: 1 * 5 mg

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Numéro de catalogue: (CAYM90245-50)

Fournisseur: Cayman Chemical

Description: STEAROYL ETHANOLAMIDE 1 * 50 mg

UOM: 1 * 50 mg

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