Votre recherche pour: \u03B2-Nicotinamide+mononucleotide

Numéro de catalogue: (PRSI3783)

Fournisseur: ProSci Inc.

Description: GAPDH Antibody: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer's and Huntington's disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

UOM: 1 * 1 EA

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Numéro de catalogue: (PRSI5003)

Fournisseur: ProSci Inc.

Description: GAPDH Antibody: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer's and Huntington's disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

UOM: 1 * 1 EA

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Numéro de catalogue: (PRSI92-711)

Fournisseur: ProSci Inc.

Description: Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are due to its role as a Nampt which can induce angiogenesis through upregulation of VEGF and VEGFR and secretion of MCP-1. Extracellular PBEF has been shown to increase inflammatory cytokines, such as TNF- alpha, IL-1 beta , IL-16, and TGF- beta 1. PBEF also increases the production of IL-6, TNF- alpha, and IL-1 beta in CD14+ monocyctes, macrophages, and dendritic cells, enhances the effectiveness of T cells.

UOM: 1 * 50 µG

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Numéro de catalogue: (PRSI56-577)

Fournisseur: ProSci Inc.

Description: NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

UOM: 1 * 400 µl

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Numéro de catalogue: (PRSI32-159)

Fournisseur: ProSci Inc.

Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. It catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Besides its functioning as a glycolytic enzyme in cytoplasm, recent evidence suggest that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of findings appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age- related neuronal diseases, such as Alzheimer’s and Huntington’s disease.

UOM: 1 * 100 µl

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Numéro de catalogue: (CAYM32883-1)

Fournisseur: Cayman Chemical

Description: NICOTINIC ACID MONONUCLEOTIDE 1 * 1 mg

UOM: 1 * 1 mg

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Numéro de catalogue: (CAYM32883-5)

Fournisseur: Cayman Chemical

Description: NICOTINIC ACID MONONUCLEOTIDE 1 * 5 mg

UOM: 1 * 5 mg

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Numéro de catalogue: (CAYM32883-10)

Fournisseur: Cayman Chemical

Description: NICOTINIC ACID MONONUCLEOTIDE 1 * 10 mg

UOM: 1 * 10 mg

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Numéro de catalogue: (PRSI36-169)

Fournisseur: ProSci Inc.

Description: Processes such as transcription, repair and replication that require efficient DNA recognition are dependent on modulation of chromatin structure. Chromatin relaxation is a critical event that occurs during DNA repair and is associated with the negatively charged polymer of adenosine 5'-diphosphate (ADP)-ribose (PAR). PAR is synthesized from nicotinamide adenine dinucleotide (NAD+) by the poly(ADP-ribose) polymerase protein family (PARPs), of which PARP-1 (and to a lesser extent PARP-2) respond to DNA-strand breaks. PARP-1 is selectively activated by DNA strand breaks to catalyze the addition of long branched chains of PAR to a variety of nuclear proteins, most notably PARP itself. The amount of PAR formed in living cells with DNA damage is commensurate with the extent of the damage. Under DNA damage conditions, PAR undergoes a rapid turnover, with a half-life in the range of minutes, as PAR is rapidly hydrolyzed and converted to free ADP-ribose by the enzyme poly(ADP-ribose)glycohydrolase (PARG). PAR regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These include transcriptional regulation, cell division, intracellular trafficking, inflammation and energy metabolism.

UOM: 1 * 1 EA

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Numéro de catalogue: (CAYM28441-5)

Fournisseur: Cayman Chemical

Description: NICOTINAMIDE N-OXIDE 1 * 5 g

UOM: 1 * 5 g

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Numéro de catalogue: (STMC07154)

Fournisseur: STEMCELL Technologies

Description: Nicotinamide 1 * 100 g

UOM: 1 * 100 g

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Numéro de catalogue: (CAYM28441-50)

Fournisseur: Cayman Chemical

Description: NICOTINAMIDE N-OXIDE 1 * 50 g

UOM: 1 * 50 g

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Numéro de catalogue: (PROOLGCFOR0552.00)

Fournisseur: LGC Standards PROMOCHEM

Description: NICOTINAMIDE 1 * 10 mg

UOM: 1 * 10 mg

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Numéro de catalogue: (CAYM28441-25)

Fournisseur: Cayman Chemical

Description: NICOTINAMIDE N-OXIDE 1 * 25 g

UOM: 1 * 25 g

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Numéro de catalogue: (CAYM23132-1)

Fournisseur: Cayman Chemical

Description: NICOTINAMIDE RIBOSIDE 1 * 1 mg

UOM: 1 * 1 mg

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Fournisseur: Apollo Scientific

Description: Riboflavine-5'-phosphate sodium salt USP

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