Imprimer

Anti-MALT1 Mouse Monoclonal Antibody [clone: MT1/410] (Alexa Fluor 488)

Fournisseur: Novus Biologicals
NOVUNBP2-33054AF48EA 596 EUR
NOVUNBP2-33054AF48
Anti-MALT1 Mouse Monoclonal Antibody [clone: MT1/410] (Alexa Fluor 488)
Anticorps
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergises with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3).

MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1) (5).

Primary antibodies are guaranteed for 1 year from date of receipt.

Attention: For research use only and is not approved for use in humans or in clinical diagnosis.

Type: Primary
Antigen: MALT1
Clonality: Monoclonal
Clone: MT1/410
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Commander maintenant

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