Imprimer

Anti-CD8A Rabbit Polyclonal Antibody (CF647) [clone: Rabbit PAb]

Fournisseur: Biotium
BNC470386-500 BNC470386-100
BNC470386-500EA 560 EUR
BNC470386-500 BNC470386-100
Anti-CD8A Rabbit Polyclonal Antibody (CF647) [clone: Rabbit PAb]
Anticorps
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Type: Primary
Antigen: CD8A
Clonality: Polyclonal
Clone: Rabbit PAb
Conjugation: CF647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
Commander maintenant

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