Votre recherche pour: Anticorps

Numéro de catalogue: (BOSSBS-11596R-A750)

Fournisseur: Bioss

Description: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-11642R-A555)

Fournisseur: Bioss

Description: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-4117R-FITC)

Fournisseur: Bioss

Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-11641R-A350)

Fournisseur: Bioss

Description: BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyze ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.

UOM: 1 * 100 µl

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Numéro de catalogue: (USBI140164)

Fournisseur: US Biological

Description: Anti-EPO Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP46272_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-CEP55 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP46058_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-AK2 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP49878_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-TREML2 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP44721_T100)

Fournisseur: Aviva Systems Biology

Description: Anti-VMA21 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Numéro de catalogue: (AVIVARP44716_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-TMEM30B Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP46778_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-C6orf10 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (AVIVARP46643_P050)

Fournisseur: Aviva Systems Biology

Description: Anti-TSPAN2 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Numéro de catalogue: (BOSSBS-2653R-A488)

Fournisseur: Bioss

Description: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-13633R-CY3)

Fournisseur: Bioss

Description: The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with muscle-specific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA) — recessively inherited disorders characterized by muscle weakness.

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-6308R-A488)

Fournisseur: Bioss

Description: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (By similarity).

UOM: 1 * 100 µl

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Numéro de catalogue: (BOSSBS-6306R-FITC)

Fournisseur: Bioss

Description: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.

UOM: 1 * 100 µl

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